- Product code: REACTI/21111
- Dosage: 25 Servings
- Size: 50gr
- Price: £16.95
Product Description:
AOR D-Mannose 50gr (25 Servings).
D-Mannose is a simple carbohydrate sugar similar in structure to glucose. When bladder infections occur, the bacteria E-coli is found in the bladder and urinary tract - where it doesn't belong. Furthermore, this bacteria has adhesion molecules (lectins) which allow it to cling to the lining of the urinary tract, making infections persistent. Some clinical experience suggests that supplemental D-mannose acts as a molecular "chaff" to which to the bacteria bind instead of to the urinary tract lining.
Although urinary tract infections (UTI s) can involve a variety of Enterobacteriaceae and gram-positive pathogens (including Staphylococcus saprophyticus and some enterococci species). Nearly all infections of the lower urinary tract and bladder are caused by a few strains of E.coli bacteria called uropathogenic Escherichia coli (UPEC). Various harmless strains of E.coli are normally present in the body – but they don’t belong in the urinary tract.
If UPEC get into the bladder or the urethra, the body has ways of fighting them off. Including the obvious method of simply flushing them out with the urine. But these bacteria have evolved ways of anchoring themselves to the cells of the urinary tract. The invading UPEC take advantage of receptors naturally found on the cells of the mucosal lining of the urinary tract. Receptors are like molecular docking bays for substances which the cells need for their normal growth and development. Like pirates in an old film, UPEC use grappling hooks called type 1 pili to first hook on to these receptors and then to invade from many of the body’s defensive immune responses. In fact, they are so sophisticated that when the body detects that cells have been infected and activates the cell suicide program to destroy the bacteria, UPEC can actually flee the dying host cell before it’s flushed out, and look for new cells to invade!
The chemical attraction between UPEC adhesions and D-Mannose is their strength – but it also provides a point of vulnerability. If you can interfere with the binding of adhesions to the O-Mannose residues in the receptors of the urinary tract cells, then you can also prevent UPEC from getting a foothold for adherence and infection. One way to do this, long known to work in a test-tube, is by using D-Mannose itself. When isolated urinary tract cells are bathed in D-Mannose, it acts as a molecular chaff. The bacterial adhesions bind to the D-Mannose in their environment instead of to the D-Mannose residues on the cells. This ums up their pili and prevents them from hooking onto urinary tract cells.
It was discovered in the late 1980 s that a small amount of D-Mannose is present in the urine normally. Apparently acting as a defensive mechanism against pathogenic bacteria. When it is taken as a supplement, much more D-Mannose passes through the urinary tract. Strengthening this natural defence.
100% Vegetarian
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SUPPLEMENT FACTS:
Serving Size: 1.1g (1/2 Teaspoon)
D-Mannose --------------------- 1.1g
Suggested Adult Intake
Take to 1/2 to 1 teaspoon (~1.1 to 2.5g) D-Mannose in water every 3 to 4 hours, or as directed by a qualified health professional.
Pregnancy / Nursing
No studies have been conducted, but believed safe. Consult with a health professional.
Cautions
None known.
AOR D-Mannose is available from Revital
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