Arginine for Weight Control

Also known as: L-Arginine

What is it?

The amino acid arginine has a few roles in the body, such as assisting in wound healing, helping remove excess ammonia from the body, stimulating immune function, and promoting secretion of a few hormones, including glucagon, insulin, and growth hormone.

Where is it found?

Dairy, meat and poultry, and fish are good sources of arginine. Nuts and chocolate also contain significant amounts of this amino acid.

Why do dieters use it?*

Some dieters say that arginine

helps reduce body fat.

What do the advocates say?*

When used while weight training, a combination of arginine and ornithine have been found to decrease body fat, resulting in higher strength and leaner muscle. Be aware, when supplementing with individual amino acids, it’s possible to upset the body’s balance of amino acids by taking just one.

How much is usually taken by dieters?

At very high intakes (approximately 250 mg per 2.2 pounds of body weight), the amino acid arginine has increased growth hormone levels,¹ an effect that has interested body builders due to the role of growth hormone in stimulating muscle growth.² However, at lower amounts recommended by some manufacturers (5 grams taken 30 minutes before exercise), arginine failed to increase growth hormone release and may even have impaired the release of growth hormone in younger adults.³

Double-blind trials conducted by one group of researchers, combining weight training with either arginine and ornithine (500 mg of each, twice per day, five times per week) or placebo, found the amino-acid combination produced decreases in body fat,⁴ resulted in higher total strength and lean body mass, and reduced evidence of tissue breakdown after only five weeks.⁵

Are there any side effects or interactions?

For most people, arginine has so far appeared to be free of obvious side effects. However, longer-term studies are needed to confirm its safety.

In a double-blind study, supplementation with 9 grams of arginine per day for six months, beginning within 3 to 21 days after a heart attack, resulted in an increase in the mortality rate.⁶ Therefore, people who have recently suffered a heart attack should probably not take large amounts of arginine. Arginine is beneficial for other manifestations of heart disease, such as heart failure and angina. However, because of the potential for arginine to cause adverse effects in heart patients, people with heart disease should consult a doctor before taking arginine.

There have been two case reports of severe allergic reactions following intravenous administration of L-arginine;⁷ however, allergic reactions have not been reported after oral administration.

People with kidney or liver disease should consult their doctor before supplementing with arginine. Some doctors believe that people with herpes (either cold sores or genital herpes) should not take arginine supplements, because of the possibility that arginine might stimulate replication of the virus.

Administration of large amounts of arginine to animals has been found both to promote⁸ and to interfere with cancer growth.⁹ In preliminary research, high intake (30 grams per day) of arginine has increased cancer cell growth in humans.¹⁰ On the other hand, in people with cancer, arginine has been found to stimulate the immune system.¹¹ At this time it remains unclear whether arginine is dangerous or helpful for people with cancer.

Arginine works with ornithine in the synthesis of growth hormone.

At the time of writing, there were no well-known drug interactions with arginine.

Resources

See a list of books, periodicals, and other resources for this and related topics.

*Dieters and weight-management advocates may claim benefits for arginine based on their personal or professional experience. These are individual opinions and testimonials that may or may not be supported by controlled clinical studies or published scientific articles on arginine. For more complete and detailed information, including references and safety information, see Arginine as a nutritional supplement.

References

1. Besset A, Bonardet A, Rondouin G, et al. Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Acta Endocrinol 1982;99:18–23.

2. Macintyre JG. Growth hormone and athletes. Sports Med 1987;4:129–42 [review].

3. Marcell TJ, Taaffe DR, Hawkins SA, et al. Oral arginine does not stimulate basal or augment exercise-induced GH secretion in either young or old adults. J Gerontol A Biol Sci Med Sci 1999;54:M395–9.

4. Elam RP. Morphological changes in adult males from resistance exercise and amino acid supplementation. J Sports Med Phys Fitness 1988;28:35–9.

5. Elam RP, Hardin DH, Sutton RA, et al. Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males. J Sports Med Phys Fitness 1989;29:52–6.

6. Schulman SP, Becker LC, Kass DA, et al. L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA 2006;295:58–64.

7. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67–8.

8. Park KGM. The immunological and metabolic effects of L-arginine in human cancer. Proc Nutr Soc 1993;52:387–401.

9. Takeda Y, Tominga T, Tei N, et al. Inhibitory effect of L-arginine on growth of rat mammary tumors induced by 7,12-dimethlybenz(a)anthracine. Cancer Res 1975;35:2390–3.

10. Park KGM. The immunological and metabolic effects of L-arginine in human cancer. Proc Nutr Soc 1993;52:387–401.

11. Brittenden J, Park KGM, Heys SD, et al. L-arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205–12.

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Learn more about the authors of Healthnotes.

The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.

2007-09-01

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