Vitamins that may be helpful
DMSO, or dimethyl sulfoxide, has a long history as a topical anti-inflammatory agent. One double-blind trial used a 10% DMSO gel topically on patients with tendinitis of the elbow and shoulder and found that it significantly reduced pain and inflammation in each joint.7 Other preliminary8 9 and double-blind10 11 trials found DMSO to be effective in treating tendinitis, but one double-blind trial found no difference between the effects of a 70% DMSO solution and a 5% DMSO placebo solution.12 Certain precautions must be taken when applying DMSO, and it should only be used under the guidance of a qualified healthcare professional.
Alternative healthcare practitioners frequently recommend proteolytic enzymes for various minor injuries. Research demonstrates that these enzymes are well absorbed when taken by mouth,13 14 and preliminary15 16 17 18 and double-blind19 20 21 22 trials have shown their effectiveness for reducing pain and swelling associated with various injuries and for speeding up the healing process. Unfortunately, many of these studies did not specifically identify the patients’ injury, so it is unclear whether the positive results included improvements in tendinitis.
Bromelain, a proteolytic enzyme, is an anti-inflammatory agent and for this reason is helpful in healing minor injuries, particularly sprains and strains,
muscle injuries, and the pain, swelling, and tenderness that
accompany sports injuries.23 24 25
Are there any side effects or interactions?
Refer to the individual supplement for information about
any side effects or interactions.
References
1. Berkow PK, Fletcher AJ, Beers MH (eds). The Merck Manual of diagnosis and therapy, 16th Ed. Rahway, NJ: Merck Research Laboratories, 1992;1367–8.
2. Latko WA. Armstrong TJ, Franzblau A, et al. Cross-sectional study of the relationship between repetitive work and the prevalence of upper limb musculoskeletal disorders. Am J Ind Med 1999;36:248–59.
3. Piligian G, Herbert R, Hearns M, et al. Evaluation and management of chronic work-related musculoskeletal disorders of the distal upper extremity. Am J Ind Med 2000;37:75–93.
4. Stock SR. Workplace ergonomic factors and the development of musculoskeletal disorders of the neck and upper limbs: a meta-analysis. Am J Ind Med 1991;19:87–107.
5. Piligian G, Herbert R, Hearns M, et al. Evaluation and management of chronic work-related musculoskeletal disorders of the distal upper extremity. Am J Ind Med, 2000;37:75–93.
6. Tittiranonda P, Rempel D, Armstrong T, Burastero S. Effect of four computer keyboards in computer users with upper extremity musculoskeletal disorders. Am J Ind Med 1999;35:647–61.
7. Kneer W, Kuhnau S, Bias P, et al. Dimethylsulfoxide (DMSO) gel in treatment of acute tendopathies. A multicenter, placebo-controlled, randomized study. Fortschritte Med 1994;112:142–6 [in German].
8. Lockie LM, Norcross BM. A clinical study on the effects of dimethyl sulfoxide in 103 patients with acute and chronic musculoskeletal injuries and inflammations. Ann N Y Acad Sci 1967;141:599–602.
9. Steinberg A. The employment of dimethyl sulfoxide as an antiinflammatory agent and steroid-transporter in diversified clinical diseases. Ann N Y Acad Sci 1967;141:532–50.
10. Brown JH, Wood DC, Jacob SW. Current status of dimethyl sulfoxide (DMSO). A double blind evaluation of its therapeutic value in acute strains, sprains, bursitis and tendonitis. Bull Soc Int Chir 1972;31:561–6.
11. Brown JH. A double blind study-DMSO for acute injuries and inflammations compared to accepted standard therapy. Curr Ther Res Clin Exp 1971;13:536–40.
12. Percy EC, Carson JD. The use of DMSO in tennis elbow and rotator cuff tendonitis: a double-blind study. Med Sci Sports Exerc 1981;13:215–9.
13. Miller JM. The absorption of proteolytic enzymes from the gastrointestinal tract. Clin Med 1968;75:35–42 [review].
14. Castell JV, Friedrich G, Kuhn CS, et al. Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake. Am J Physiol 1997;273:G139–46.
15. Cirelli MG. Five years’ experience with bromelains in therapy of edema and inflammation in postoperative tissue reaction, skin infections and trauma. Clin Med 1967;74:55–9.
16. Trickett P. Proteolytic enzymes in treatment of athletic injuries. Appl Ther 1964;6:647–52.
17. Sweeny FJ. Treatment of athletic injuries with an oral proteolytic enzyme. Med Times 1963:91:765.
18. Boyne PS, Medhurst H. Oral anti-inflammatory enzyme therapy in injuries in professional footballers. Practitioner 1967;198:543–6.
19. Deitrick RE. Oral proteolytic enzymes in the treatment of athletic injuries: A double-blind study. Pennsylvania Med J 1965;Oct:35–7.
20. Holt HT. Carica papaya as ancillary therapy for athletic injuries. Curr Ther Res 1969;11:621–4.
21. Rathgeber WF. The use of proteolytic enzymes (Chymoral) in sporting injuries. S Afr Med J 1971;45:181–3.
22. Buck JE, Phillips N. Trial of Chymoral in professional footballers. Br J Clin Pract 1970;24:375–7.
23. Seligman B. Bromelain: an anti-inflammatory agent.
Angiology 1962;13:508–10.
24. Cirelli MG. Treatment of inflammation and edema
with bromelain. Delaware Med J 1962;34:159–67.
25. Masson M. Bromelain in
the treatment of blunt injuries to the musculoskeletal system. A case observation study by an
orthopedic surgeon in private practice. Fortschr Med 1995;113:303–6.
26. Kleinhenz J, Streitberger K, Windeler J, et al. Randomised clinical trial comparing the effects of acupuncture and a newly designed placebo needle in rotator cuff tendinitis. Pain 1999;83:235–41.
27. Haker E, Lundeberg T. Acupuncture treatment in epicondylalgia: a comparative study of two acupuncture techniques. Clin J Pain 1990;6:221–6.
28. Haker E, Lundeberg T. Laser treatment applied to acupuncture points in lateral humeral epicondylalgia. A double-blind study. Pain 1990;43:243–7.
29. Ebenbichler GR, Erdogmus CB, Resch KL, et al. Ultrasound therapy for calcific tendonitis of the shoulder. N Engl J Med 1999;340:1533–8.
30. van der Windt DA, van der Heijden GJ, van den Berg SG, et al. Ultrasound therapy for musculoskeletal disorders: a systematic review. Pain 1999;81:257–71.
31. Klaiman MD, Shrader JA, Danoff JV, et al. Phonophoresis versus ultrasound in the treatment of common musculoskeletal conditions. Med Sci Sports Exerc 1998;30:1349–55.
32. Kaada B. Treatment of peritendinitis calcarea of the shoulder by transcutaneous nerve stimulation. Acupunct Electrother Res 1984;9:115–25.
33. Saveriano G, Lionetti P, Maiolo F, Battisti E. Our experience in the use of a new objective pain measuring system in rheumarthropatic subjects treated with transcutaneous electroanalgesia and ultrasound. Minerva Med 1986;77:745–52 [in Italian].