Active constituents
Peppermint leaves yield approximately 0.1–1.0% volatile oil which is composed primarily of menthol (29–48%) and menthone (20–31%).2 Peppermint oil is classified as a carminative (prevents and relieves intestinal wind).3 It may also relieve spasms in the intestinal tract. Peppermint oil or peppermint tea is often used to treat wind and indigestion.
Three double-blind trials found that enteric-coated peppermint oil reduced the pain associated with intestinal spasms, commonly experienced in irritable bowel syndrome (IBS).4 5 6 However, another trial found no effect of peppermint on IBS.7 A double-blind trial found that an enteric-coated combination of peppermint and caraway oils was superior to a placebo for people with gastro-intestinal complaints including IBS.8 A combination of peppermint, caraway seeds, and two other carminative herbs (fennel seeds and wormwood) was reported to be effective for gastro-intestinal complaints including IBS in another double-blind study.9
A tea of peppermint is a traditional therapy for colic in babies but has never been investigated in a human trial. Peppermint should be used cautiously in babies (see side effects below).
Peppermint oil’s relaxing action also extends to topical use. When applied topically, it acts as an analgesic and reduces pain.10 A trial of topical peppermint oil applied to the temples of healthy volunteers (with or without eucalyptus oil) found that peppermint oil had a muscle-relaxing action and it decreased tension.11 Topical peppermint oil alone reduced pain in people with tension headaches as well.
References
1. Foster S. Herbs for Your Health. Loveland, CO: Interweave Press, 1996, 72–3.
2. Bradley PR (ed). British Herbal Compendium, vol 1. Bournemouth, Dorset UK: British Herbal Medicine Association, 1992, 174–6.
3. Tyler VE. Herbs of Choice: The Therapeutic Use of Phytomedicinals. Binghamton, NY: Pharmaceutical Products Press, 1994, 56–7.
4. Dew MJ, Evans BK, Rhodes J. Peppermint oil for the irritable bowel syndrome: a multicenter trial. Br J Clin Pract 1984;38:394–8.
5. Liu J-H, Chen G-H, Yeh H-Z, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765–8.
6. Rees W, Evans B, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979; 2:835–6.
7. Nash P, Gould SR, Barnardo DB. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292–3.
8. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149–53.
9. Westphal J, Hörning M, Leonhardt K. Phytotherapy in functional abdominal complaints: Results of a clinical study with a preparation of several plants. Phytomedicine 1996;2:285–91.
10. Göbel H, Schmidt G, Dwoshak M, et al. Essential plant oils and headache mechanisms. Phytomedicine 1995;2:93–102.
11. Göbel H, Schmidt G, Soyka DS. Effect of peppermint and eucalyptus oil preparations on neurophysiological and experimental algesimetric headache parameters. Cephalalgia 1994;14:228–34.
12. Wichtl M. Herbal Drugs and Phytopharmaceuticals. Boca Raton, FL: CRC Press, 1994, 336–8.
13. Sigmund DJ, McNally EF. The action of a carminative on the lower esophageal sphincter. Gastroent 1969;56:13–8.
14. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 180–2.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.