Are there any side effects or interactions?
As with aspirin, some people may experience stomach upset from taking willow. Although such symptoms are less likely from willow than from aspirin, people with ulcers and gastritis should, nevertheless, avoid this herb.9 Again, as with aspirin, willow should not be used to treat fevers in children since it may cause Reye’s syndrome.
There is one published report of a severe allergic reaction (anaphylaxis) occurring in a person who took a supplement that contained willow bark.10 The possibility of allergy to willow bark should be considered by anyone who is allergic to aspirin or other salicylates.
Are there any drug interactions?
Certain medicines may interact with willow. Refer to drug interactions for a list of those medicines.
References
1. Weiss RF. Herbal Medicine. Gothenburg, Sweden: Ab Arcanum, 1988, 31, 303.
2. Foster S. 101 Medicinal Herbs. Loveland, CO: Interweave Press, 1998, 210–1.
3. Bradley PR (ed). British Herbal Compendium, vol 1. Bournemouth, Dorset, UK: British Herbal Medicine Association, 1992, 224–6.
4. Mills SY, Jacoby RK, Chacksfield M, Willoughby M. Effect of a proprietary herbal medicine on the relief of chronic arthritic pain: A double-blind study. Br J Rheum 1996;35:874–8.
5. Schmid B, Tschirdewahn B, Kàtter I, et al. Analgesic effects of willow bark extract in osteoarthritis: results of a clinical double-blind trial. Fact 1998;3:186.
6. Chrubasik S, Eisenberg E, Balan E, et al. Treatment of low back pain exacerbations with willow bark extract: A randomized double-blind study. Am J Med 2000;109:9–14.
7. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 230.
8. Chrubasik S, Eisenberg E, Balan E, et al. Treatment of low back pain exacerbations with willow bark extract: A randomized double-blind study. Am J Med 2000;109:9–14.
9. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 230.
10. Boullata JI, McDonnell PJ, Oliva CD. Anaphylactic reaction to a
dietary supplement containing willow bark. Ann Pharmacother 2003;37:832–5.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.